Cord blood allergen-specific IgE is associated with reduced IFN-gamma production by cord blood cells: the Protection against Allergy-Study in Rural Environments (PASTURE) Study. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Allergy and Clinical Immunology Année : 2008

Cord blood allergen-specific IgE is associated with reduced IFN-gamma production by cord blood cells: the Protection against Allergy-Study in Rural Environments (PASTURE) Study.

Petra Ina Pfefferle
  • Fonction : Auteur
Serdar Sel
  • Fonction : Auteur
Markus Johannes Ege
  • Fonction : Auteur
Gisela Büchele
  • Fonction : Auteur
Nicole Blümer
  • Fonction : Auteur
Susanne Krauss-Etschmann
  • Fonction : Auteur
Ileana Herzum
  • Fonction : Auteur
Christoph E Albers
  • Fonction : Auteur
Roger P Lauener
  • Fonction : Auteur
Marjut Roponen
  • Fonction : Auteur
Maija-Riitta Hirvonen
  • Fonction : Auteur
Josef Riedler
  • Fonction : Auteur
Charlotte Braun-Fahrländer
  • Fonction : Auteur
Juha Pekkanen
  • Fonction : Auteur
Erika von Mutius
  • Fonction : Auteur
Harald Renz
  • Fonction : Auteur
Non Renseigné
  • Fonction : Auteur

Résumé

BACKGROUND: It is currently discussed whether allergic sensitization may start in utero under the influence of the maternal immune system and environmental determinants. OBJECTIVE: To investigate the relationship between allergen-specific cord blood (CB) IgE levels, parental sensitization, CB cytokine production, and environmental influences. METHODS: As part of an ongoing multicenter birth cohort study, allergen-specific IgE antibodies against 20 common seasonal, perennial, and food allergens were measured in blood samples from 922 neonates, 922 mothers, and 835 fathers. Supernatants from stimulated CB cells were assessed for the production of IL-5, IFN-gamma, IL-10, and TNF-alpha. RESULTS: Allergen-specific IgE antibodies were detectable in 23.9% of newborns. Contamination with maternal serum was excluded by several means of analyses, including the absence of IgA antibodies. Clear correlation between maternal and fetal IgE was found only for hen's egg, cow's milk, and soybean allergen. Fetal IgE correlated negatively with the level of IFN-gamma production, but not with IL-5 and IL-10. CONCLUSION: Allergen-specific IgE antibodies most probably of fetal origin are detectable in CB and correlate with a lowered CB IFN-gamma production.

Dates et versions

hal-00462275 , version 1 (09-03-2010)

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Petra Ina Pfefferle, Serdar Sel, Markus Johannes Ege, Gisela Büchele, Nicole Blümer, et al.. Cord blood allergen-specific IgE is associated with reduced IFN-gamma production by cord blood cells: the Protection against Allergy-Study in Rural Environments (PASTURE) Study.. Journal of Allergy and Clinical Immunology, 2008, 122 (4), pp.711-6. ⟨10.1016/j.jaci.2008.06.035⟩. ⟨hal-00462275⟩
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