Low-resolution Electromagnetic Brain Tomography (LORETA) of Monozygotic Twins Discordant for Chronic Fatigue Syndrome
Résumé
Background: Previous work using quantified EEG has suggested that brain activity in individuals with chronic fatigue syndrome (CFS) and normal persons differs. Our objective was to investigate if specific frequency band-pass regions and spatial locations are associated with CFS using low-resolution electromagnetic brain tomography (LORETA). Methods: We conducted a co-twin control study of 17 pairs of monozygotic twins where 1 twin met criteria for CFS and the co-twin was healthy. Twins underwent an extensive battery of tests including a structured psychiatric interview and a quantified EEG. Eyes closed EEG frequencydomain analysis was computed and the entire brain volume was compared of the CFS and healthy twins using a multiple comparison procedure. Results: Compared with their healthy co-twins, twins with CFS differed in current source density. The CFS twins had higher delta in the left uncus and parahippocampal gyrus and higher theta in the cingulate gyrus and right superior frontal gyrus. Conclusions: These findings suggest that neurophysiological activity in specific areas of the brain may differentiate individuals with CFS from those in good health. These preliminary findings await replication.
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