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PubMed : 18773151

PubMed Central : 2826869

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Biological Trace Element Research 126 (2008) Pages 80-96

Burn-induced oxidative stress is altered by a low zinc status: kinetic study in burned rats fed a low zinc diet.

Richard Claeyssen (  Auteur correspondant ) 1, 2, Maud Andriollo-Sanchez 2, Josiane Arnaud 1, 3, Laurence Touvard 2, Antonia Alonso 2, Yves Chancerelle 2, Anne-Marie Roussel 1, Diane Agay 2

(04/08/2008)

As an initial subdeficient status of zinc, considered as an essential antioxidant trace element, is frequent in burned patients, we aim to assess the effects of low zinc dietary intakes on burn-induced oxidative stress, in an animal model. After 8 weeks of conditioning diets containing 80 ppm (control group) or 10 ppm of zinc (depleted group), Wistar rats were 20% TBSA burned and sampled 1-10 days after injury. Kinetic evolutions of zinc status, plasma oxidative stress parameters, and antioxidant enzymes were also studied in blood and organs. The zinc-depleted diet induced, before injury, a significant decrease in zinc bone level and the increase of oxidative stress markers without stimulation of antioxidant enzyme activity. After burn, more markedly in zinc depleted animals than in controls, zinc levels decreased in plasma and bone, while increasing in liver. The decrease of thiol groups and GSH/GSSG ratio and the depression of GPx activity in liver are also moderately emphasized. Nevertheless, depleted zinc status could not be considered as determining for oxidative damages after burn injury. Further investigations must also be done to enlighten the mechanism of beneficial effects of zinc supplementation reported in burned patients.

1 :	Bioenergétique fondamentale et appliquée (LBFA)
	INSERM : U884 – Université Joseph Fourier - Grenoble I
2 :	Centre de Recherches du Service de Santé des Armées (CRSSA)
	Service de Santé des Armées
3 :	Département de biologie intégrée
	Centre Hospitalier Universitaire Grenoble – Hôpital Michallon

Équipe de recherche : INSERM U884 Laboratoire de Bioénergétique Fondamentale et Appliquée ; Centre de Recherche du Service de Santé des Armées.

Domaine

:

Sciences du Vivant/Médecine humaine et pathologie Sciences du Vivant/Alimentation et Nutrition Sciences du Vivant/Biologie animale

Mots Clés : Burn injury – Zinc intakes – Zinc status – Oxidative stress – Rat model

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Contributeur : Richard Claeyssen <>

Soumis le : Mardi 9 Février 2010, 15:08:59

Dernière modification le : Mardi 9 Février 2010, 16:42:59