Model predictive control during the primary drying stage of lyophilisation

Nawal Daraoui (1) , Pascal Dufour (1) , Hassan Hammouri (1) , Aurélie Hottot (1)

1 LAGEP - Laboratoire d'automatique et de génie des procédés

During the primary drying stage of pharmaceutical solutions in vial, the sublimation front position is the boundary between the dried and frozen layers that moves from the top of the vial to its bottom. It is an important variable to control, while few on-line measures are available. This paper deals with the on-line partial differential equation model-based predictive control of the sublimation front position, assuming two strategies based on various availability of measurement used in the feedback loop. Through the MPC@CB control software, the robustness of the controller with respect to the main model parameter uncertainty is shown.

Mots clés: Process control; model predictive control; chemical engineering; lyophilisation; drying; heat transfer; mass transfer.; mass transfer

Domaines: Automatique / Robotique

Nawal Daraoui, Pascal Dufour, Hassan Hammouri, Aurélie Hottot. Model predictive control during the primary drying stage of lyophilisation. Control Engineering Practice, 2010, 18 (5), pp.483-494. ⟨10.1016/j.conengprac.2010.01.005⟩. ⟨hal-00434481⟩