Ecological factors influencing the transfer of plasmids in vitro and in vivo

Denis E. Corpet (1, 2)

1 Xénobiotiques
2 Laboratoire d'écologie microbienne

Plasmid transfer in the gut depends on the concentrations of recipient and donor bacteria and on their fertility. The main determining factors for the former are flow rate, concentration of limiting substrate, growth rates, adhesion, contamination and segregation and of the latter plasmid content, growth phase, and ecological conditions. These factors have to be measured with experimental models, and included in mathematical models, to estimate their relative incidence.

Mots clés: plasmid transfer; in vitro; in vivo; gut; intestinal ecology; fertility; flow rate; limiting substrate; growth rates; adhesion; contamination; segregation; growth phase; ecological conditions; experimental models; mathematical models; Escherichia coli; continuous flow culture; chemostat; R-factor

Domaines: Cancer

Denis E. Corpet. Ecological factors influencing the transfer of plasmids in vitro and in vivo. Journal of Antimicrobial Chemotherapy, 1986, 18 (Suppl. C), pp.127-132. ⟨hal-00430677⟩