A Boolean Model of Molecular Signaling Pathways

Olivier Niel (1)

1 Department of Biology

The usual representation of signaling pathways in molecular biology consists of diagrams. These diagrams are often unclear and confusing, thus making global understanding, prediction and computerization of the signaling pathways impossible. Here we propose a novel representation of signaling pathways, based on a mathematical model. This model associates a simple equation with any signaling pathway. We used this model to study several pathways, such as Akt, leading to strong predictions and powerful in silico experiments.

Mots clés: Boolean; signaling pathway; Akt; set theory; bioinformatics

Domaines: Modélisation et simulation; Organisation et fonctions cellulaires [q-bio.SC]; Logique [math.LO]

Olivier Niel. A Boolean Model of Molecular Signaling Pathways. CPBT-08, Apr 2009, Toulon, France. Part2, p3. ⟨hal-00405173⟩