| HAL : hal-00397235, version 1 |
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| Refining Dynamics of Gene Regulatory Networks in a Stochastic π-Calculus Framework |
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Loïc Paulevé 1Morgan Magnin 1 |
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| (19/06/2009) |
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| In this paper, we introduce a framework allowing to model and analyse efficiently Gene Regulatory Networks in their temporal and stochastic aspects. The analysis of stable states and inference of René Thomas' discrete parameters derives from this logical formalism. We offer a compositional approach which comes with a natural translation to the Stochastic π-Calculus. The method we propose consists in successive refinements of generalized dynamics of Gene Regulatory Networks. We apply this method to the control of the differentiation in a Gene Regulatory Network generalizing metazoan segmentation processes. |
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| 1 : | Institut de Recherche en Communications et en Cybernétique de Nantes (IRCCyN) |
| CNRS : UMR6597 – Université de Nantes – École Centrale de Nantes – Ecole des Mines de Nantes – Ecole Polytechnique de l'Université de Nantes | |
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| Moves (IRCCyN, Nantes, FR) |
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| Domaine | : | Informatique/Bio-informatique Informatique/Modélisation et simulation |
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| Gene regulatory networks – Temporal and stochastic parameters – René Thomas' parameters inference – Stochastic pi-calculus. |
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| Liste des fichiers attachés à ce document : | |||||
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| hal-00397235, version 1 | |
| http://hal.archives-ouvertes.fr/hal-00397235 | |
| oai:hal.archives-ouvertes.fr:hal-00397235 | |
| Contributeur : Loïc Paulevé | |
| Soumis le : Vendredi 19 Juin 2009, 18:17:04 | |
| Dernière modification le : Vendredi 19 Juin 2009, 23:24:09 | |