Global Asymptotic Stability and Hopf Bifurcation for a Blood Cell Production Model

Fabien Crauste (1)

1 LMAP - Laboratoire de Mathématiques et de leurs Applications [Pau]

We analyze the asymptotic stability of a nonlinear system of two differential equations with delay describing the dynamics of blood cell production. This process takes place in the bone marrow where stem cells differentiate throughout divisions in blood cells. Taking into account an explicit role of the total population of hematopoietic stem cells on the introduction of cells in cycle, we are lead to study a characteristic equation with delay-dependent coefficients. We determine a necessary and sufficient condition for the global stability of the first steady state of our model, which describes the population's dying out, and we obtain the existence of a Hopf bifurcation for the only nontrivial positive steady state, leading to the existence of periodic solutions. These latter are related to dynamical diseases affecting blood cells known for their cyclic nature.

Mots clés: asymptotic stability; delay differential equations; characteristic equation; delay dependent coefficients; Hopf bifurcation; blood cell model; stem cells

Domaines: Equations aux dérivées partielles [math.AP]

Fabien Crauste. Global Asymptotic Stability and Hopf Bifurcation for a Blood Cell Production Model. Mathematical Biosciences and Engineering, 2006, 3 (2), pp.325-346. ⟨hal-00376070v2⟩