A Physical Model for Studying Adhesion between a Living Cell and a Spherical Functionalized Substrate

Elisabetta Canetta (1) , Anne Leyrat (1) , Claude Verdier (1)

1 LR - Laboratoire de rhéologie

A new microadhesion experiment is analysed in the framework of a stochastic model. Particular attention is focused on the adhesion between a functionalized spherical microsphere and a cell grown on a substrate. The parameters governing the dynamics of failure are deduced from the theory and the geometry of the system.

Mots clés: Multiple bonds; Adhesion; JKR; Binding kinetics; Rupture force; Multiple bonds.

Domaines: Bio-Informatique, Biologie Systémique [q-bio.QM]; Bio-informatique [q-bio.QM]; Biophysique [physics.bio-ph]

Elisabetta Canetta, Anne Leyrat, Claude Verdier. A Physical Model for Studying Adhesion between a Living Cell and a Spherical Functionalized Substrate. Mathematical and Computer Modelling, 2003, 37, pp.1121-1129. ⟨hal-00322178⟩