Colon tumor promotion, is it a selection process? Effects of cholate, phytate, and food restriction in rats on proliferation and apoptosis in normal and aberrant crypts. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cancer Letters Année : 1997

Colon tumor promotion, is it a selection process? Effects of cholate, phytate, and food restriction in rats on proliferation and apoptosis in normal and aberrant crypts.

Denis E. Corpet
  • Fonction : Auteur correspondant
Sylviane Taché
  • Fonction : Auteur
Ginette Peiffer
  • Fonction : Auteur

Résumé

Promotion would suppose the selection of initiated cells. We tested the selection of aberrant crypt cells by cholic acid, a colon cancer promoter, and the effect of protectors, phytate and food restriction. After an azoxymethane injection, rats were allocated to a control diet, or to supplements of cholic acid, sodium phytate, or to a 50% food restriction. The proliferation and apoptosis of 1200 crypts were assessed, after immuno-staining for BrdU. Cholic acid increased the proliferation of aberrant crypts but not of normal crypts. Phytate and food restriction decreased the proliferation of normal crypts, but not of aberrant crypts. Apoptosis was not affected by diets. Results support the hypothesis that cholic acid can select initiated cells in the colon.
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Dates et versions

hal-00283712 , version 1 (10-06-2008)

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Denis E. Corpet, Sylviane Taché, Ginette Peiffer. Colon tumor promotion, is it a selection process? Effects of cholate, phytate, and food restriction in rats on proliferation and apoptosis in normal and aberrant crypts.. Cancer Letters, 1997, 114, pp.135-138. ⟨hal-00283712⟩
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