Ewod Digital Microfluidics for Lab On a Chip

Yves Fouillet (1) , D. Jary (1) , A.G. Brachet (1) , Jean Berthier (1) , R. Blervaque (1) , Laurent Davoust (2) , Jean-Maxime Roux (2) , Jean-Luc Achard (2) , C. Peponnet (1)

1 CEA - Commissariat à l'énergie atomique et aux énergies alternatives
2 LEGI - Laboratoire des Écoulements Géophysiques et Industriels [Grenoble]

This paper presents a brief overview of Electro Wetting On Dielectric (EWOD) microdroplet actuation technology fluidic behaviour. EWOD specifics are compared with other digital microfluidics actuation modes. In particular ease of integration with complex protocols is emphasized. After reviewing the electro-wetting principle and various Electro-Hydro-Dynamic phenomena; we compare various EWOD configurations for Lab on a Chip. Two fluid functionalities will be detailed: on-chip droplet dispensing, and mixing. We cover chip architecture and the benefits of organizing these chips as fluidic microprocessors. Finally, real time Polymerase Chain Reaction within a 64 nl droplet is described as an illustration of a biological application using EWOD.

Domaines: Mécanique des fluides [physics.class-ph]; Mécanique des fluides [physics.class-ph]

Yves Fouillet, D. Jary, A.G. Brachet, Jean Berthier, R. Blervaque, et al.. Ewod Digital Microfluidics for Lab On a Chip. ASME 4th International Conference on Nanochannels, Microchannels, and Minichannels, Jun 2006, Limerick, Ireland. ⟨10.1115/ICNMM2006-96020⟩. ⟨hal-00189272⟩