General Methodology for Metabolic Pathways Modeling and Simulation using Discrete Event Approach. Example on glycolysis of Yeast.

Thierry Antoine-Santoni (1) , Fabrice Bernardi (1) , François Giamarchi (1)

1 SPE - Sciences pour l'environnement

In the Bioinformatics research domain, the systemics approach (considering a cell as a system) is growing up very quickly. Most of the significant current researches focus on mathematical formalisms. However, the discrete event simulation domain is so mature nowadays, that it can be considered as the pending of differential equations in the continuous models domain. In this paper, we introduce a general methodology using the DEVS formalism in the bioinformatics domain and to apply it to the modeling and simulation of a metabolic pathway, the glycolysis.

Mots clés: DEVS; Methodology; Bioinformatic; Glycolysis

Domaines: Modélisation et simulation

Thierry Antoine-Santoni, Fabrice Bernardi, François Giamarchi. General Methodology for Metabolic Pathways Modeling and Simulation using Discrete Event Approach. Example on glycolysis of Yeast.. BIOCOMP 2007, Jun 2007, Las Vegas, United States. pp.58-64. ⟨hal-00178790⟩