%0 Journal Article
%T Small Angle Scattering and Zeta Potential of Liposomes Loaded with Octa(carboranyl)porphyrazine
%+ Dipartimento di Chimica 'Ugo Schiff' [Sesto Fiorentino] (DICUS UniFI)
%+ Laboratoire des colloïdes, verres et nanomatériaux (LCVN)
%+ Laboratoire Interdisciplinaire sur l'Organisation Nanométrique et Supramoléculaire (LIONS)
%+ Department of Chemistry, Basilicata
%+ Department of Chemistry University “La Sapienza”
%A Salvati, Anna
%A Ristori, Sandra
%A Oberdisse, Julian
%A Spalla, Olivier
%A Ricciardi, Giampaolo
%A Pietrangeli, Daniela
%A Giustini, Mauro
%A Martini, Giacomo
%< avec comité de lecture
%@ 1520-6106
%J Journal of Physical Chemistry B
%I American Chemical Society
%V 111
%P 10357-10364
%8 2007-08-14
%D 2007
%Z 0709.0830
%R 10.1021/jp0731710
%K Liposome
%K Carboranylporphyrazine
%K Boronated compounds
%K SAXS
%K SANS
%Z Physics [physics]/Condensed Matter [cond-mat]/Soft Condensed Matter [cond-mat.soft]
%Z Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph]Journal articles
%X In this work the physicochemical characterization of liposomes loaded with a newly synthesised carboranyl porphyrazine (H2HECASPz) is described. This molecule represents a potential drug for different anticancer therapies, such as Boron Neutron Capture Therapy, Photodynamic Therapy and Photothermal Therapy. Different loading methods and different lipid mixtures were tested. The corresponding loaded vectors were studied by Small Angle Scattering (SANS and SAXS), light scattering and zeta potential. The combined analysis of structural data at various length scales and the measurement of the surface charge allowed to obtain a detailed characterization of the investigated systems. The mechanisms underlying the onset of differences in relevant physicochemical parameters (size, polydispersity and charge) were also critically discussed.
%G English
%2 https://hal.science/hal-00170093/document
%2 https://hal.science/hal-00170093/file/Salvati_Porphyrazine_liposomes_Final.pdf
%L hal-00170093
%U https://hal.science/hal-00170093
%~ CEA
%~ CNRS
%~ UNIV-MONTP2
%~ LCVN
%~ PUBNIMBE
%~ IRAMIS-NIMBE
%~ UNIV-MONTPELLIER
%~ IRAMIS
%~ GS-PHYSIQUE
%~ UM1-UM2
%~ TEST2-HALCNRS