Small Angle Scattering and Zeta Potential of Liposomes Loaded with Octa(carboranyl)porphyrazine

Anna Salvati (1) , Sandra Ristori (1) , Julian Oberdisse (2) , Olivier Spalla (3) , Giampaolo Ricciardi (4) , Daniela Pietrangeli (4) , Mauro Giustini (5) , Giacomo Martini (1)

1 DICUS UniFI - Dipartimento di Chimica 'Ugo Schiff' [Sesto Fiorentino]
2 LCVN - Laboratoire des colloïdes, verres et nanomatériaux
3 LIONS - Laboratoire Interdisciplinaire sur l'Organisation Nanométrique et Supramoléculaire
4 Department of Chemistry, Basilicata
5 Department of Chemistry University “La Sapienza”

In this work the physicochemical characterization of liposomes loaded with a newly synthesised carboranyl porphyrazine (H2HECASPz) is described. This molecule represents a potential drug for different anticancer therapies, such as Boron Neutron Capture Therapy, Photodynamic Therapy and Photothermal Therapy. Different loading methods and different lipid mixtures were tested. The corresponding loaded vectors were studied by Small Angle Scattering (SANS and SAXS), light scattering and zeta potential. The combined analysis of structural data at various length scales and the measurement of the surface charge allowed to obtain a detailed characterization of the investigated systems. The mechanisms underlying the onset of differences in relevant physicochemical parameters (size, polydispersity and charge) were also critically discussed.

Mots clés: Liposome; Carboranylporphyrazine; Boronated compounds; SAXS; SANS

Domaines: Matière Molle [cond-mat.soft]; Biophysique [physics.bio-ph]

Anna Salvati, Sandra Ristori, Julian Oberdisse, Olivier Spalla, Giampaolo Ricciardi, et al.. Small Angle Scattering and Zeta Potential of Liposomes Loaded with Octa(carboranyl)porphyrazine. Journal of Physical Chemistry B, 2007, 111, pp.10357-10364. ⟨10.1021/jp0731710⟩. ⟨hal-00170093⟩