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Article Dans Une Revue FEBS Letters Année : 2005

alpha7B integrin changes in mdx mouse muscles after L-arginine administration.

Résumé

Muscle fibers attach to laminin in the basal lamina using two mechanisms, i.e., dystrophin with its associated proteins and alpha7beta1 integrin. In humans, gene-mutation defects in one member of these complexes result in muscular dystrophies. This study revealed changes after L-arginine treatment of utrophin-associated proteins and the alpha7B integrin subunit in mdx mouse, a dystrophin-deficient animal model. In the two studied muscles (cardiac muscle and diaphragm), the alpha7B integrin subunit was increased in 5-week-old treated mice. Interestingly, the diaphragm histopathological appearance was significantly improved by L-arginine administration. These results highlight a possible way to compensate for dystrophin deficiency via alpha7beta1 integrin.
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Dates et versions

hal-00143841 , version 1 (27-04-2007)

Identifiants

Citer

Delphine Chazalette, Karim Hnia, François Rivier, Gérald Hugon, Dominique Mornet. alpha7B integrin changes in mdx mouse muscles after L-arginine administration.. FEBS Letters, 2005, 579 (5), pp.1079-84. ⟨10.1016/j.febslet.2004.12.081⟩. ⟨hal-00143841⟩
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