Advanced Waldenstrom's macroglobulinemia: usefulness of Morel's scoring system in establishing prognosis.

R. Porcher (1) , S. Chevret (1) , E. Wattel (2, 3) , V. Leblond (4) , V. Levy (1, 5) , Pierre Morel (6)

1 Biostatistique et épidémiologie clinique
2 VPV - Virologie et pathogenèse virale
3 Département de Biostatistique et Informatique Médicale
4 CHU Pitié-Salpêtrière [AP-HP]
5 Centre d'Investigations Cliniques
6 Service d'Hématologie Clinique

New treatments for patients with Waldenstrom's macroglobulinemia (WM) have necessited the development of prognostic indices. Using a sample of 92 patients with refractory or relapsing WM treated in a randomized trial, we show that Morel's prognostic scoring system for patients at diagnosis is also effective in patients with advanced disease.

Mots clés: Aged; Antineoplastic Agents/pharmacology; Cohort Studies; Cyclophosphamide/administration & dosage; Doxorubicin/administration & dosage; Drug Therapy; Combination; Humans; Male; Middle Aged; Multivariate Analysis; Prednisone/administration & dosage; Prognosis; Time Factors; Vidarabine/analogs & derivatives/therapeutic use; Waldenstrom Macroglobulinemia/*diagnosis/*therapy

Domaines: Virologie

R. Porcher, S. Chevret, E. Wattel, V. Leblond, V. Levy, et al.. Advanced Waldenstrom's macroglobulinemia: usefulness of Morel's scoring system in establishing prognosis.. Haematologica, 2005, pp.281. ⟨hal-00125029⟩