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Article Dans Une Revue Funct Integr Genomics Année : 2001

Gene induction during differentiation of human monocytes into dendritic cells: an integrated study at the RNA and protein levels.

Résumé

Changes in gene expression occurring during differentiation of human monocytes into dendritic cells were studied at the RNA and protein levels. These studies showed the induction of several gene classes corresponding to various biological functions. These functions encompass antigen processing and presentation, cytoskeleton, cell signalling and signal transduction, but also an increase in mitochondrial function and in the protein synthesis machinery, including some, but not all, chaperones. These changes put in perspective the events occurring during this differentiation process. On a more technical point, it appears that the studies carried out at the RNA and protein levels are highly complementary.
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Dates et versions

hal-00118427 , version 1 (05-12-2006)

Identifiants

Citer

Catherine Angénieux, Dominique Fricker, Jean-Marc Strub, Sylvie Luche, Huguette Bausinger, et al.. Gene induction during differentiation of human monocytes into dendritic cells: an integrated study at the RNA and protein levels.. Funct Integr Genomics, 2001, 1 (5), pp.323-9. ⟨10.1007/s101420100037⟩. ⟨hal-00118427⟩
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