Trinucleotide repeat expansion In vivo Oligodendrocytes Centronuclear myopathy BIOLOGIE MOLECULAIRE Cardiac muscle Dynamin 2 Diaphragm Glial cells Lc3 Central nervous system Brain Thérapie génique GABA DMPK Gene therapy Antisense oligonucleotide ARN Autophagy Glucocorticoids Myostatin Acetylcholinesterase deficiency Gene editing RNA biology CMS Myelin Exercise CRISPRi Skeletal muscle Transgenic mouse ACETYLCHOLINESTERASE Muscular dystrophy Glucocorticoid-receptor Myotonic Dystrophy Type 1 CRISPR/Cas9 Trinucleotide Repeat Expansion Myotonic Dystrophy type 1 Glutamate Therapy Transcriptomics Quantitative microdialysis Genotype phenotype correlation GSK3␤ Expression Antisense oligonucleotides Heart failure Mice Alternative splicing Gene Therapy CTG repeats KNOCKOUT MICE DM1 DMSXL mice MBNL Exercice Long read sequencing Dilated cardiomyopathy Aging Muscle AAV PacBio Cytoskeleton Brain dysfunction Astrocytes Oligodendrocyte Myotonic dystrophy mouse models Knockout Cell penetrating peptide Intermediate filament Mouse model Duchenne muscular dystrophy RNA splicing PCR Male Dystrophie Myotonique Mouse models CTG repeat instability Maximal force Hypoxia Motoneuron Dystrophie myotonique CONGENITAL MYATHENIC SYNDROME Cell culture model Neuron CTG repeat contractions Fibrosis Astrocyte Animals Myotonic dystrophy type 1 Myotonic Dystrophy Acetylcholinesterase knockout mouse Heart Acute coronary syndrome Myotonic dystrophy Desmin Transgenic mouse model Cell model Dystrophin RNA interference Humans