Biocompatible Periodic Mesoporous Ionosilica Nanoparticles with Ammonium Walls: Application to Drug Delivery

Roza Bouchal (1) , Morgane Daurat (2, 3) , Magali Gary-Bobo (2) , Afitz da Silva (2, 3) , Leila Lesaffre (2) , Dina Aggad (2) , Anastasia Godefroy (2, 3) , Philippe Dieudonne-George (4) , Clarence Charnay (1) , Jean-Olivier Durand (1) , Peter Hesemann (1)

1 ICGM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
2 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]
3 NMS - NanoMedSyn
4 L2C - Laboratoire Charles Coulomb

Periodic mesoporous ionosilica nanoparticles with ammonium walls were synthesized exclusively from a trisilylated ammonium precursor. The nanoparticles display a uniform particle size, together with a high specific surface area and an ordered hexagonal pore architecture. Completely biocompatible in vitro and in vivo, the nanoparticles are efficiently endocytosed by RAW 264.7 macrophages and used as carrier vehicles for anionic drugs. Diclofenac-loaded ionosilica nanoparticles are very efficient in inhibiting lipopolysaccharides-induced inflammation.

Mots clés: ionosilica; periodic mesoporous organosilica; nanoparticles; anion exchange; drug delivery

Domaines: Matériaux

Roza Bouchal, Morgane Daurat, Magali Gary-Bobo, Afitz da Silva, Leila Lesaffre, et al.. Biocompatible Periodic Mesoporous Ionosilica Nanoparticles with Ammonium Walls: Application to Drug Delivery. ACS Applied Materials & Interfaces, 2017, 9, pp.32018-32025. ⟨10.1021/acsami.7b07264⟩. ⟨hal-01625845⟩