Drug-Polymer Electrostatic Complexes as New Structuring Agents for the Formation of Drug-Loaded Ordered Mesoporous Silica

Emilie Molina (1) , Jerome Warnant (1) , Melody Mathonnat (1) , Mael Bathfield (1) , Martin In (2, 3) , Danielle Laurencin (1) , Christine Jérôme (4) , Patrick Lacroix-Desmazes (1) , Nathalie Marcotte (1) , Corine Gerardin (1)

1 ICGM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
2 L2C - Laboratoire Charles Coulomb
3 Matière Molle
4 CERM

Using aminoglycoside antibiotics as drug models, it was shown that electrostatic complexes between hydrophilic drugs and oppositely charged double-hydrophilic block copolymers can form ordered mesophases. This phase behavior was evidenced by using poly(acrylic acid)-block-poly(ethylene oxide) block copolymers in the presence of silica precursors, and this allowed preparing drug-loaded mesoporous silica directly from the drug-polymer complexes. The novel synthetic strategy of the hybrid materials is highly efficient, avoiding waste and multistep processes; it also ensures optimal drug loading and provides pH-dependence of the drug release from the materials.

Domaines: Polymères; Matériaux; Science des matériaux [cond-mat.mtrl-sci]

Emilie Molina, Jerome Warnant, Melody Mathonnat, Mael Bathfield, Martin In, et al.. Drug-Polymer Electrostatic Complexes as New Structuring Agents for the Formation of Drug-Loaded Ordered Mesoporous Silica. Langmuir, 2015, 31 (47), pp.12839-12844. ⟨10.1021/acs.langmuir.5b03221⟩. ⟨hal-01257693⟩